The Effects of Lipoic Acid on Yolk Nutrient Utilization, Energy Metabolism, and Redox Balance over Time in Artemia sp.

Lipoic acid (LA) is a mitochondrial coenzyme that, depending on the concentration and exposure time, can behave as an antioxidant or pro-oxidant agent has proven ability to modulate metabolism by promoting lipid glucose oxidation for energy production. To assess effects of LA redox balance over Artemia sp. nauplii was used animal model. The administered concentrations were 0.05, 0.1, 0.5, 1.0, 5.0, 10.0 µM. Therefore, possible differences in protein, triglyceride, glucose, lactate artemia samples total ammoniacal nitrogen (TAN) culture water evaluated. We also measured vivo activity electron transport system (ETS), capacity, production reactive oxygen species (ROS) at 6, 12, 18, 24 h post-hatching. There decrease LA-treated animals, ammonia observed 0.5 µM treatment. ETS positively regulated addition LA, with most significant 5.0 12 h. For activity, treatments presented highest values h, period when ROS decreased significantly, treatment showed positive regulation together TAN excretion.